Names & Taxonomy
- Uniprot ID:
- Q16772
- Entry Name:
- GSTA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3)
- Gene Names:
- GSTA3
- Gene Names Primary:
- GSTA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 222
- Sequence:
- MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAKIALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPLLKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=23 uM for delta(5)-androstene-3,17-dione
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytosol
extracellular exosome
glutathione transferase activity
glutathione derivative biosynthetic process
glutathione metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- glutathione derivative biosynthetic process
glutathione metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione transferase activity
- Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Polymorphism
Reference proteome
Transferase