Names & Taxonomy
- Uniprot ID:
- Q16739
- Entry Name:
- CEGT_HUMAN
- Status:
- reviewed
- Protein Names:
- Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)
- Gene Names:
- UGCG
- Gene Names Primary:
- UGCG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 394
- Sequence:
- MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
- Pathway:
- Lipid metabolism; sphingolipid metabolism.
- Catalytic Activity:
- UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.
- Active Site:
- ACT_SITE 236 236 Proton acceptor.
- Cross Reference Drug Bank:
- DB09039 DB00419
- Gene Ontology Go:
- Golgi membrane
integral component of membrane
membrane
ceramide glucosyltransferase activity
epidermis development
glucosylceramide biosynthetic process
glycosphingolipid biosynthetic process
glycosphingolipid metabolic process
positive regulation of protein targeting to mitochondrion
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- epidermis development
glucosylceramide biosynthetic process
glycosphingolipid biosynthetic process
glycosphingolipid metabolic process
positive regulation of protein targeting to mitochondrion
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- ceramide glucosyltransferase activity
- Gene Ontology Cellular Component:
- Golgi membrane
integral component of membrane
membrane - Keywords:
- Acetylation
Complete proteome
Glycosyltransferase
Golgi apparatus
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane
Transmembrane helix