Names & Taxonomy

Uniprot ID:
Q16739
Entry Name:
CEGT_HUMAN
Status:
reviewed
Protein Names:
Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)
Gene Names:
UGCG
Gene Names Primary:
UGCG
Organism:
Homo sapiens (Human)

Structure

Length:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Golgi apparatus membrane

Function

Function:
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
Pathway:
Lipid metabolism; sphingolipid metabolism.
Catalytic Activity:
UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.
Active Site:
ACT_SITE 236 236 Proton acceptor.
Cross Reference Drug Bank:
DB09039 DB00419
Gene Ontology Go:
Golgi membrane
integral component of membrane
membrane
ceramide glucosyltransferase activity
epidermis development
glucosylceramide biosynthetic process
glycosphingolipid biosynthetic process
glycosphingolipid metabolic process
positive regulation of protein targeting to mitochondrion
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Biological Process:
epidermis development
glucosylceramide biosynthetic process
glycosphingolipid biosynthetic process
glycosphingolipid metabolic process
positive regulation of protein targeting to mitochondrion
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Molecular Function:
ceramide glucosyltransferase activity
Gene Ontology Cellular Component:
Golgi membrane
integral component of membrane
membrane
Keywords:
Acetylation
Complete proteome
Glycosyltransferase
Golgi apparatus
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8643456 14702039 15164053 15489334