Names & Taxonomy
- Uniprot ID:
- Q16671
- Entry Name:
- AMHR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
- Gene Names:
- AMHR2 AMHR MISR2
- Gene Names Primary:
- AMHR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 573
- Sequence:
- MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 333 333 Proton acceptor.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- integral component of plasma membrane
anti-Mullerian hormone receptor activity
ATP binding
hormone binding
metal ion binding
receptor activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type II
female gonad development
male gonad development
Mullerian duct regression
negative regulation of anti-Mullerian hormone signaling pathway
sex differentiation
signal transduction
transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- female gonad development
male gonad development
Mullerian duct regression
negative regulation of anti-Mullerian hormone signaling pathway
sex differentiation
signal transduction
transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- anti-Mullerian hormone receptor activity
ATP binding
hormone binding
metal ion binding
receptor activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type II - Gene Ontology Cellular Component:
- integral component of plasma membrane
- Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Pseudohermaphroditism
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- P08238