Names & Taxonomy

Uniprot ID:
Q16568
Entry Name:
CART_HUMAN
Status:
reviewed
Protein Names:
Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)]
Gene Names:
CARTPT CART
Gene Names Primary:
CARTPT
Organism:
Homo sapiens (Human)

Structure

Length:
116
Sequence:
MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEVLKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
Cross Reference Drug Bank:
DB00182
Gene Ontology Go:
extracellular space
secretory granule
activation of MAPKK activity
adult feeding behavior
cell-cell signaling
cellular glucose homeostasis
cellular response to starvation
circadian regulation of gene expression
G-protein coupled receptor signaling pathway
negative regulation of appetite
negative regulation of bone resorption
negative regulation of glucagon secretion
negative regulation of osteoclast differentiation
neuropeptide signaling pathway
positive regulation of blood pressure
positive regulation of epinephrine secretion
positive regulation of transmission of nerve impulse
regulation of insulin secretion
signal transduction
somatostatin secretion
synaptic transmission
Gene Ontology Biological Process:
activation of MAPKK activity
adult feeding behavior
cell-cell signaling
cellular glucose homeostasis
cellular response to starvation
circadian regulation of gene expression
G-protein coupled receptor signaling pathway
negative regulation of appetite
negative regulation of bone resorption
negative regulation of glucagon secretion
negative regulation of osteoclast differentiation
neuropeptide signaling pathway
positive regulation of blood pressure
positive regulation of epinephrine secretion
positive regulation of transmission of nerve impulse
regulation of insulin secretion
signal transduction
somatostatin secretion
synaptic transmission
Gene Ontology Cellular Component:
extracellular space
secretory granule
Keywords:
3D-structure
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Neuropeptide
Neurotransmitter
Obesity
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal
Interacts With:
P13688; P40199

Publication

PubMed ID:
8647455 15489334 15340161 9590691 11478874 10905499 11522684