Names & Taxonomy

Uniprot ID:
Q16134
Entry Name:
ETFD_HUMAN
Status:
reviewed
Protein Names:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)
Gene Names:
ETFDH
Gene Names Primary:
ETFDH
Organism:
Homo sapiens (Human)

Structure

Length:
617
Sequence:
MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion inner membrane.
Intramembrane:
INTRAMEM 109 130

Function

Function:
Accepts electrons from ETF and reduces ubiquinone.
Catalytic Activity:
Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.
Cofactor:
COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883; ; Note=Binds 1 cluster.;; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
Gene Ontology Go:
integral component of mitochondrial inner membrane
mitochondrial matrix
mitochondrial membrane
4 iron, 4 sulfur cluster binding
electron carrier activity
electron-transferring-flavoprotein dehydrogenase activity
flavin adenine dinucleotide binding
metal ion binding
oxidoreductase activity
oxidoreductase activity, oxidizing metal ions with flavin as acceptor
quinone binding
ubiquinone binding
cellular metabolic process
electron transport chain
fatty acid beta-oxidation using acyl-CoA dehydrogenase
respiratory electron transport chain
response to oxidative stress
small molecule metabolic process
Gene Ontology Biological Process:
cellular metabolic process
electron transport chain
fatty acid beta-oxidation using acyl-CoA dehydrogenase
respiratory electron transport chain
response to oxidative stress
small molecule metabolic process
Gene Ontology Molecular Function:
4 iron, 4 sulfur cluster binding
electron carrier activity
electron-transferring-flavoprotein dehydrogenase activity
flavin adenine dinucleotide binding
metal ion binding
oxidoreductase activity
oxidoreductase activity, oxidizing metal ions with flavin as acceptor
quinone binding
ubiquinone binding
Gene Ontology Cellular Component:
integral component of mitochondrial inner membrane
mitochondrial matrix
mitochondrial membrane
Keywords:
4Fe-4S
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Electron transport
FAD
Flavoprotein
Glutaricaciduria
Iron
Iron-sulfur
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Transport
Ubiquinone

Publication

PubMed ID:
8306995 14702039 17974005 15815621 15489334 12815589 21269460 24275569 25944712 12359134 16527485 16959974 17412732 19249206 20370797