Names & Taxonomy
- Uniprot ID:
- Q16134
- Entry Name:
- ETFD_HUMAN
- Status:
- reviewed
- Protein Names:
- Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)
- Gene Names:
- ETFDH
- Gene Names Primary:
- ETFDH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 617
- Sequence:
- MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane.
- Intramembrane:
- INTRAMEM 109 130
Function
- Function:
- Accepts electrons from ETF and reduces ubiquinone.
- Catalytic Activity:
- Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883; ; Note=Binds 1 cluster.;; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Gene Ontology Go:
- integral component of mitochondrial inner membrane
mitochondrial matrix
mitochondrial membrane
4 iron, 4 sulfur cluster binding
electron carrier activity
electron-transferring-flavoprotein dehydrogenase activity
flavin adenine dinucleotide binding
metal ion binding
oxidoreductase activity
oxidoreductase activity, oxidizing metal ions with flavin as acceptor
quinone binding
ubiquinone binding
cellular metabolic process
electron transport chain
fatty acid beta-oxidation using acyl-CoA dehydrogenase
respiratory electron transport chain
response to oxidative stress
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
electron transport chain
fatty acid beta-oxidation using acyl-CoA dehydrogenase
respiratory electron transport chain
response to oxidative stress
small molecule metabolic process - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
electron carrier activity
electron-transferring-flavoprotein dehydrogenase activity
flavin adenine dinucleotide binding
metal ion binding
oxidoreductase activity
oxidoreductase activity, oxidizing metal ions with flavin as acceptor
quinone binding
ubiquinone binding - Gene Ontology Cellular Component:
- integral component of mitochondrial inner membrane
mitochondrial matrix
mitochondrial membrane - Keywords:
- 4Fe-4S
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Electron transport
FAD
Flavoprotein
Glutaricaciduria
Iron
Iron-sulfur
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Transport
Ubiquinone