Names & Taxonomy
- Uniprot ID:
- Q15849
- Entry Name:
- UT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
- Gene Names:
- SLC14A2 HUT2 UT2
- Gene Names Primary:
- SLC14A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 920
- Sequence:
- MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKYQAYDVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane; Multi-pass membrane protein.
Function
- Function:
- Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
- Cross Reference Drug Bank:
- DB03904
- Gene Ontology Go:
- apical plasma membrane
integral component of membrane
integral component of plasma membrane
membrane
plasma membrane
cell adhesion molecule binding
urea channel activity
urea transmembrane transporter activity
response to water deprivation
transmembrane transport
urea transport - Gene Ontology Biological Process:
- response to water deprivation
transmembrane transport
urea transport - Gene Ontology Molecular Function:
- cell adhesion molecule binding
urea channel activity
urea transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of membrane
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- O95295