Names & Taxonomy

Uniprot ID:
Q15758
Entry Name:
AAAT_HUMAN
Status:
reviewed
Protein Names:
Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)
Gene Names:
SLC1A5 ASCT2 M7V1 RDR RDRC
Gene Names Primary:
SLC1A5
Organism:
Homo sapiens (Human)

Structure

Length:
541
Sequence:
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).
Cross Reference Drug Bank:
DB00174 DB00130
Gene Ontology Go:
extracellular exosome
Golgi apparatus
integral component of plasma membrane
melanosome
membrane
plasma membrane
L-glutamine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
receptor activity
sodium:dicarboxylate symporter activity
virus receptor activity
amino acid transport
glutamine transport
ion transport
neutral amino acid transport
transmembrane transport
Gene Ontology Biological Process:
amino acid transport
glutamine transport
ion transport
neutral amino acid transport
transmembrane transport
Gene Ontology Molecular Function:
L-glutamine transmembrane transporter activity
neutral amino acid transmembrane transporter activity
receptor activity
sodium:dicarboxylate symporter activity
virus receptor activity
Gene Ontology Cellular Component:
extracellular exosome
Golgi apparatus
integral component of plasma membrane
melanosome
membrane
plasma membrane
Keywords:
Acetylation
Alternative initiation
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Host cell receptor for virus entry
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q99942

Publication

PubMed ID:
8702519 10051606 10196349 14702039 15057824 15489334 11350958 10708449 17081983 17081065 18669648 19413330 19349973 19690332 20068231 21269460 21406692 22814378 23492904 25944712