Names & Taxonomy
- Uniprot ID:
- Q15311
- Entry Name:
- RBP1_HUMAN
- Status:
- reviewed
- Protein Names:
- RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1)
- Gene Names:
- RALBP1 RLIP1 RLIP76
- Gene Names Primary:
- RALBP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 655
- Sequence:
- MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
- Cross Reference Drug Bank:
- DB00564 DB00997 DB00398 DB00541
- Gene Ontology Go:
- cytosol
membrane
ATPase activity
ATPase activity, coupled to movement of substances
GTPase activator activity
Rac GTPase binding
Ral GTPase binding
transmembrane transporter activity
chemotaxis
endocytosis
positive regulation of GTPase activity
regulation of GTPase activity
regulation of small GTPase mediated signal transduction
signal transduction
small GTPase mediated signal transduction
transmembrane transport
transport - Gene Ontology Biological Process:
- chemotaxis
endocytosis
positive regulation of GTPase activity
regulation of GTPase activity
regulation of small GTPase mediated signal transduction
signal transduction
small GTPase mediated signal transduction
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATPase activity
ATPase activity, coupled to movement of substances
GTPase activator activity
Rac GTPase binding
Ral GTPase binding
transmembrane transporter activity - Gene Ontology Cellular Component:
- cytosol
membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
GTPase activation
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transport - Interacts With:
- Q9H6F0; Q9Y2J4-4; Q8TAB5; P78556; Q86XR8; Q13227; O60437; Q969G3; Q86VP1; Q05BL0; G5E9B5; Q15025; Q96C28