Names & Taxonomy

Uniprot ID:
Q15274
Entry Name:
NADC_HUMAN
Status:
reviewed
Protein Names:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)
Gene Names:
QPRT
Gene Names Primary:
QPRT
Organism:
Homo sapiens (Human)

Structure

Length:
297
Sequence:
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
Proteomes:
UP000005640

Function

Function:
Involved in the catabolism of quinolinic acid (QA).
Pathway:
Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.
Catalytic Activity:
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP)
Enzyme Regulation:
ENZYME REGULATION: Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
Cross Reference Drug Bank:
DB00627
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nicotinate-nucleotide diphosphorylase (carboxylating) activity
protein homodimerization activity
NAD biosynthetic process
NAD metabolic process
protein oligomerization
quinolinate catabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
NAD biosynthetic process
NAD metabolic process
protein oligomerization
quinolinate catabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
nicotinate-nucleotide diphosphorylase (carboxylating) activity
protein homodimerization activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
Keywords:
3D-structure
Complete proteome
Glycosyltransferase
Polymorphism
Pyridine nucleotide biosynthesis
Reference proteome
Transferase

Publication

PubMed ID:
9473669 15489334 24275569 17868694 21269460