Names & Taxonomy

Uniprot ID:
Q15262
Entry Name:
PTPRK_HUMAN
Status:
reviewed
Protein Names:
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Gene Names:
PTPRK PTPK
Gene Names Primary:
PTPRK
Organism:
Homo sapiens (Human)

Structure

Length:
1439
Sequence:
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.

Function

Function:
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 1082 1082 Phosphocysteine intermediate.
Gene Ontology Go:
adherens junction
axon
cell surface
cell-cell junction
dendrite
integral component of membrane
integral component of plasma membrane
leading edge membrane
neuronal cell body
photoreceptor outer segment
beta-catenin binding
gamma-catenin binding
protein kinase binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
cell adhesion
cell migration
cellular response to reactive oxygen species
cellular response to UV
focal adhesion assembly
negative regulation of cell cycle
negative regulation of cell migration
negative regulation of cell proliferation
negative regulation of keratinocyte proliferation
negative regulation of transcription, DNA-templated
neuron projection development
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
protein localization to cell surface
signal transduction
transforming growth factor beta receptor signaling pathway
Gene Ontology Biological Process:
cell adhesion
cell migration
cellular response to reactive oxygen species
cellular response to UV
focal adhesion assembly
negative regulation of cell cycle
negative regulation of cell migration
negative regulation of cell proliferation
negative regulation of keratinocyte proliferation
negative regulation of transcription, DNA-templated
neuron projection development
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
protein localization to cell surface
signal transduction
transforming growth factor beta receptor signaling pathway
Gene Ontology Molecular Function:
beta-catenin binding
gamma-catenin binding
protein kinase binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
adherens junction
axon
cell-cell junction
cell surface
dendrite
integral component of membrane
integral component of plasma membrane
leading edge membrane
neuronal cell body
photoreceptor outer segment
Keywords:
3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Membrane
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
P04626; P28300; Q02763

Publication

PubMed ID:
8663237 9047348 14574404 15489334 19836242 19159218 19349973 24275569 19167335