Names & Taxonomy
- Uniprot ID:
- Q15125
- Entry Name:
- EBP_HUMAN
- Status:
- reviewed
- Protein Names:
- 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)
- Gene Names:
- EBP
- Gene Names Primary:
- EBP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 230
- Sequence:
- MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
- Pathway:
- Steroid biosynthesis; cholesterol biosynthesis.
- Catalytic Activity:
- 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol.
- Cross Reference Drug Bank:
- DB00675
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
C-8 sterol isomerase activity
cholestenol delta-isomerase activity
drug transmembrane transporter activity
steroid delta-isomerase activity
transmembrane signaling receptor activity
cholesterol biosynthetic process
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
cholesterol metabolic process
drug transmembrane transport
hemopoiesis
signal transduction
skeletal system development
small molecule metabolic process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
cholesterol metabolic process
drug transmembrane transport
hemopoiesis
signal transduction
skeletal system development
small molecule metabolic process - Gene Ontology Molecular Function:
- C-8 sterol isomerase activity
cholestenol delta-isomerase activity
drug transmembrane transporter activity
steroid delta-isomerase activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane - Keywords:
- Acetylation
Cataract
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Disease mutation
Dwarfism
Endoplasmic reticulum
Ichthyosis
Isomerase
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transmembrane
Transmembrane helix