Names & Taxonomy
- Uniprot ID:
- Q15111
- Entry Name:
- PLCL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP)
- Gene Names:
- PLCL1
- Gene Names Primary:
- PLCL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1095
- Sequence:
- MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRDRRSGVALPGAAGTPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
- Cross Reference Drug Bank:
- DB01103
- Gene Ontology Go:
- cytoplasm
plasma membrane
inositol 1,4,5 trisphosphate binding
phosphatidylinositol phospholipase C activity
phospholipase C activity
signal transducer activity
gamma-aminobutyric acid signaling pathway
intracellular signal transduction
lipid metabolic process
positive regulation of receptor binding
regulation of peptidyl-serine phosphorylation
regulation of synaptic transmission, GABAergic - Gene Ontology Biological Process:
- gamma-aminobutyric acid signaling pathway
intracellular signal transduction
lipid metabolic process
positive regulation of receptor binding
regulation of peptidyl-serine phosphorylation
regulation of synaptic transmission, GABAergic - Gene Ontology Molecular Function:
- inositol 1,4,5 trisphosphate binding
phosphatidylinositol phospholipase C activity
phospholipase C activity
signal transducer activity - Gene Ontology Cellular Component:
- cytoplasm
plasma membrane - Keywords:
- Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Phosphoprotein
Polymorphism
Reference proteome
Transducer