Names & Taxonomy

Uniprot ID:
Q15080
Entry Name:
NCF4_HUMAN
Status:
reviewed
Protein Names:
Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox)
Gene Names:
NCF4 SH3PXD4
Gene Names Primary:
NCF4
Organism:
Homo sapiens (Human)

Structure

Length:
339
Sequence:
MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
Cross Reference Drug Bank:
DB00514
Gene Ontology Go:
cytosol
endosome membrane
membrane
NADPH oxidase complex
phagolysosome
phosphatidylinositol-3-phosphate binding
protein dimerization activity
superoxide-generating NADPH oxidase activator activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
immune response
oxidation-reduction process
positive regulation of catalytic activity
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
immune response
oxidation-reduction process
positive regulation of catalytic activity
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
phosphatidylinositol-3-phosphate binding
protein dimerization activity
superoxide-generating NADPH oxidase activator activity
Gene Ontology Cellular Component:
cytosol
endosome membrane
membrane
NADPH oxidase complex
phagolysosome
Keywords:
3D-structure
Alternative splicing
Chronic granulomatous disease
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Endosome
Lipid-binding
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Interacts With:
P14598; P19878

Publication

PubMed ID:
8280052 8839867 10437784 15461802 14702039 10591208 15489334 9804763 11684018 12887891 15657040 17290225 19692703