Names & Taxonomy
- Uniprot ID:
- Q15080
- Entry Name:
- NCF4_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox)
- Gene Names:
- NCF4 SH3PXD4
- Gene Names Primary:
- NCF4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 339
- Sequence:
- MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
- Cross Reference Drug Bank:
- DB00514
- Gene Ontology Go:
- cytosol
endosome membrane
membrane
NADPH oxidase complex
phagolysosome
phosphatidylinositol-3-phosphate binding
protein dimerization activity
superoxide-generating NADPH oxidase activator activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
immune response
oxidation-reduction process
positive regulation of catalytic activity
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
immune response
oxidation-reduction process
positive regulation of catalytic activity
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- phosphatidylinositol-3-phosphate binding
protein dimerization activity
superoxide-generating NADPH oxidase activator activity - Gene Ontology Cellular Component:
- cytosol
endosome membrane
membrane
NADPH oxidase complex
phagolysosome - Keywords:
- 3D-structure
Alternative splicing
Chronic granulomatous disease
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Endosome
Lipid-binding
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain - Interacts With:
- P14598; P19878