Names & Taxonomy
- Uniprot ID:
- Q15075
- Entry Name:
- EEA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)
- Gene Names:
- EEA1 ZFYVE2
- Gene Names Primary:
- EEA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1411
- Sequence:
- MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDLQG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Function
- Function:
- Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
- Gene Ontology Go:
- axonal spine
cytoplasm
cytoplasmic vesicle
cytosol
early endosome
early endosome membrane
extracellular exosome
extrinsic component of plasma membrane
membrane
recycling endosome
serine-pyruvate aminotransferase complex
1-phosphatidylinositol binding
calmodulin binding
GTP-dependent protein binding
protein homodimerization activity
zinc ion binding
early endosome to late endosome transport
endocytosis
synaptic vesicle to endosome fusion
vesicle fusion - Gene Ontology Biological Process:
- early endosome to late endosome transport
endocytosis
synaptic vesicle to endosome fusion
vesicle fusion - Gene Ontology Molecular Function:
- 1-phosphatidylinositol binding
calmodulin binding
GTP-dependent protein binding
protein homodimerization activity
zinc ion binding - Gene Ontology Cellular Component:
- axonal spine
cytoplasm
cytoplasmic vesicle
cytosol
early endosome
early endosome membrane
extracellular exosome
extrinsic component of plasma membrane
membrane
recycling endosome
serine-pyruvate aminotransferase complex - Keywords:
- 3D-structure
Coiled coil
Complete proteome
Cytoplasm
Direct protein sequencing
Endosome
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Zinc
Zinc-finger - Interacts With:
- P04626; Q9UL26; P20339; P61020; Q5K651; Q69Z37; Q63635