Names & Taxonomy

Uniprot ID:
Q15031
Entry Name:
SYLM_HUMAN
Status:
reviewed
Protein Names:
Probable leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)
Gene Names:
LARS2 KIAA0028
Gene Names Primary:
LARS2
Organism:
Homo sapiens (Human)

Structure

Length:
903
Sequence:
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Catalytic Activity:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).
Cross Reference Drug Bank:
DB00149
Gene Ontology Go:
mitochondrial matrix
mitochondrion
aminoacyl-tRNA editing activity
ATP binding
leucine-tRNA ligase activity
gene expression
leucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
leucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
aminoacyl-tRNA editing activity
ATP binding
leucine-tRNA ligase activity
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Deafness
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide

Publication

PubMed ID:
7584026 15489334 19608861 20194621 21269460 25944712 23541342