Names & Taxonomy
- Uniprot ID:
- Q15031
- Entry Name:
- SYLM_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)
- Gene Names:
- LARS2 KIAA0028
- Gene Names Primary:
- LARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 903
- Sequence:
- MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).
- Cross Reference Drug Bank:
- DB00149
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
aminoacyl-tRNA editing activity
ATP binding
leucine-tRNA ligase activity
gene expression
leucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
leucyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- aminoacyl-tRNA editing activity
ATP binding
leucine-tRNA ligase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Complete proteome
Deafness
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide