Names & Taxonomy
- Uniprot ID:
- Q14CN2
- Entry Name:
- CLCA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form]
- Gene Names:
- CLCA4 CaCC2 UNQ562/PRO1124
- Gene Names Orf:
- UNQ562/PRO1124
- Gene Names Primary:
- CLCA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 919
- Sequence:
- MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTASTYLFEATEKRFFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQFTECGEKGEYIHFTPDLLLGKKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSKKIEATRCSAGISGRNRVYKCQGGSCLSRACRIDSTTKLYGKDCQFFPDKVQTEKASIMFMQSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSEDFKNTIPMVTPPPPPVFSLLKISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFDSTATIVNKLIQIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTASSCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGNTDLSQKSLQLESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIMENFTVDATSKMAYLSIPGTAKVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKMNKDVNSFPSPMIVYAEILQGYVPVLGANVTAFIESQNGHTEVLELLDNGAGADSFKNDGVYSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAYIPGWVVNGEIEANPPRPEIDEDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKIILTWTAPGDNFDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATHIFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTLVLSVIGSVVIVNFILSTTI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- May be involved in mediating calcium-activated chloride conductance.
- Gene Ontology Go:
- apical plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
chloride channel activity
intracellular calcium activated chloride channel activity
metal ion binding
metallopeptidase activity
chloride transmembrane transport
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- chloride transmembrane transport
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- chloride channel activity
intracellular calcium activated chloride channel activity
metal ion binding
metallopeptidase activity - Gene Ontology Cellular Component:
- apical plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Autocatalytic cleavage
Cell membrane
Chloride
Complete proteome
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Transport
Zinc