Names & Taxonomy

Uniprot ID:
Q14957
Entry Name:
NMDE3_HUMAN
Status:
reviewed
Protein Names:
Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
Gene Names:
GRIN2C NMDAR2C
Gene Names Primary:
GRIN2C
Organism:
Homo sapiens (Human)

Structure

Length:
1233
Sequence:
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Function

Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Cross Reference Drug Bank:
DB00659 DB00289 DB00996 DB00145 DB06738 DB04896 DB00312 DB00454 DB01174 DB00418
Gene Ontology Go:
cell junction
integral component of plasma membrane
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic density
postsynaptic membrane
cation channel activity
extracellular-glutamate-gated ion channel activity
NMDA glutamate receptor activity
activation of MAPKK activity
axon guidance
directional locomotion
epidermal growth factor receptor signaling pathway
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glutamate receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of protein catabolic process
neuromuscular process controlling balance
neurotrophin TRK receptor signaling pathway
protein localization
Ras protein signal transduction
response to wounding
small GTPase mediated signal transduction
synaptic transmission
transport
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
axon guidance
directional locomotion
epidermal growth factor receptor signaling pathway
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glutamate receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of protein catabolic process
neuromuscular process controlling balance
neurotrophin TRK receptor signaling pathway
protein localization
Ras protein signal transduction
response to wounding
small GTPase mediated signal transduction
synaptic transmission
transport
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
cation channel activity
extracellular-glutamate-gated ion channel activity
NMDA glutamate receptor activity
Gene Ontology Cellular Component:
cell junction
integral component of plasma membrane
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic density
postsynaptic membrane
Keywords:
Calcium
Cell junction
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Magnesium
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q62936; P78352; P31016

Publication

PubMed ID:
9037519 16625196 15489334 21300787