Names & Taxonomy
- Uniprot ID:
- Q14749
- Entry Name:
- GNMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine N-methyltransferase (EC 2.1.1.20)
- Gene Names:
- GNMT
- Gene Names Primary:
- GNMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 295
- Sequence:
- MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
- Catalytic Activity:
- S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
- Cross Reference Drug Bank:
- DB00145 DB00118
- Gene Ontology Go:
- cytoplasm
folic acid binding
glycine binding
glycine N-methyltransferase activity
cellular nitrogen compound metabolic process
cellular protein modification process
glycogen metabolic process
methionine metabolic process
one-carbon metabolic process
protein homotetramerization
regulation of gluconeogenesis
S-adenosylmethionine metabolic process
selenium compound metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular protein modification process
glycogen metabolic process
methionine metabolic process
one-carbon metabolic process
protein homotetramerization
regulation of gluconeogenesis
S-adenosylmethionine metabolic process
selenium compound metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- folic acid binding
glycine binding
glycine N-methyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Folate-binding
Methyltransferase
Phosphoprotein
Reference proteome
S-adenosyl-L-methionine
Transferase - Interacts With:
- P49407