Names & Taxonomy

Uniprot ID:
Q14697
Entry Name:
GANAB_HUMAN
Status:
reviewed
Protein Names:
Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha)
Gene Names:
GANAB G2AN KIAA0088
Gene Names Primary:
GANAB
Organism:
Homo sapiens (Human)

Structure

Length:
944
Sequence:
MAAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPYRALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKPAAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum

Function

Function:
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
Pathway:
Glycan metabolism; N-glycan metabolism.
Catalytic Activity:
Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans.
Active Site:
ACT_SITE 542 542 Nucleophile.; ACT_SITE 545 545
Cross Reference Drug Bank:
DB00491
Gene Ontology Go:
endoplasmic reticulum lumen
extracellular exosome
glucosidase II complex
Golgi apparatus
melanosome
membrane
carbohydrate binding
glucan 1,3-alpha-glucosidase activity
poly(A) RNA binding
cellular protein metabolic process
post-translational protein modification
protein folding
protein N-linked glycosylation via asparagine
Gene Ontology Biological Process:
cellular protein metabolic process
post-translational protein modification
protein folding
protein N-linked glycosylation via asparagine
Gene Ontology Molecular Function:
carbohydrate binding
glucan 1,3-alpha-glucosidase activity
poly(A) RNA binding
Gene Ontology Cellular Component:
endoplasmic reticulum lumen
extracellular exosome
glucosidase II complex
Golgi apparatus
melanosome
membrane
Keywords:
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Glycosidase
Golgi apparatus
Hydrolase
Polymorphism
Reference proteome
Signal

Publication

PubMed ID:
10929008 16554811 7788527 15489334 3881423 8910335 17081065 21269460 24275569 25944712