Names & Taxonomy
- Uniprot ID:
- Q14697
- Entry Name:
- GANAB_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha)
- Gene Names:
- GANAB G2AN KIAA0088
- Gene Names Primary:
- GANAB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 944
- Sequence:
- MAAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPYRALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKPAAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
- Pathway:
- Glycan metabolism; N-glycan metabolism.
- Catalytic Activity:
- Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans.
- Active Site:
- ACT_SITE 542 542 Nucleophile.; ACT_SITE 545 545
- Cross Reference Drug Bank:
- DB00491
- Gene Ontology Go:
- endoplasmic reticulum lumen
extracellular exosome
glucosidase II complex
Golgi apparatus
melanosome
membrane
carbohydrate binding
glucan 1,3-alpha-glucosidase activity
poly(A) RNA binding
cellular protein metabolic process
post-translational protein modification
protein folding
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- cellular protein metabolic process
post-translational protein modification
protein folding
protein N-linked glycosylation via asparagine - Gene Ontology Molecular Function:
- carbohydrate binding
glucan 1,3-alpha-glucosidase activity
poly(A) RNA binding - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
extracellular exosome
glucosidase II complex
Golgi apparatus
melanosome
membrane - Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Glycosidase
Golgi apparatus
Hydrolase
Polymorphism
Reference proteome
Signal