Names & Taxonomy

Uniprot ID:
Q14574
Entry Name:
DSC3_HUMAN
Status:
reviewed
Protein Names:
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene Names:
DSC3 CDHF3 DSC4
Gene Names Primary:
DSC3
Organism:
Homo sapiens (Human)

Structure

Length:
896
Sequence:
MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Function

Function:
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Gene Ontology Go:
cell-cell junction
desmosome
integral component of membrane
membrane
plasma membrane
calcium ion binding
gamma-catenin binding
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
protein stabilization
Gene Ontology Biological Process:
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
protein stabilization
Gene Ontology Molecular Function:
calcium ion binding
gamma-catenin binding
Gene Ontology Cellular Component:
cell-cell junction
desmosome
integral component of membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Glycoprotein
Hypotrichosis
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7929347 7665906 11027496 16177791 19765682