Names & Taxonomy
- Uniprot ID:
- Q14574
- Entry Name:
- DSC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
- Gene Names:
- DSC3 CDHF3 DSC4
- Gene Names Primary:
- DSC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 896
- Sequence:
- MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Function
- Function:
- Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
- Gene Ontology Go:
- cell-cell junction
desmosome
integral component of membrane
membrane
plasma membrane
calcium ion binding
gamma-catenin binding
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
protein stabilization - Gene Ontology Biological Process:
- cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
protein stabilization - Gene Ontology Molecular Function:
- calcium ion binding
gamma-catenin binding - Gene Ontology Cellular Component:
- cell-cell junction
desmosome
integral component of membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Glycoprotein
Hypotrichosis
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix