Names & Taxonomy
- Uniprot ID:
- Q14563
- Entry Name:
- SEM3A_HUMAN
- Status:
- reviewed
- Protein Names:
- Semaphorin-3A (Semaphorin III) (Sema III)
- Gene Names:
- SEMA3A SEMAD
- Gene Names Primary:
- SEMA3A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 771
- Sequence:
- MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
- Gene Ontology Go:
- axon
dendrite
extracellular region
extracellular space
chemorepellent activity
neuropilin binding
semaphorin receptor binding
apoptotic process
axon extension involved in axon guidance
axon guidance
axonal fasciculation
axonogenesis involved in innervation
branchiomotor neuron axon guidance
dendrite morphogenesis
dichotomous subdivision of terminal units involved in salivary gland branching
facial nerve structural organization
facioacoustic ganglion development
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
negative regulation of axon extension involved in axon guidance
negative regulation of epithelial cell migration
nerve development
neural crest cell migration
neural crest cell migration involved in autonomic nervous system development
neural crest cell migration involved in sympathetic nervous system development
neuron migration
olfactory bulb development
positive regulation of male gonad development
positive regulation of neuron migration
regulation of axon extension involved in axon guidance
regulation of heart rate
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
sensory system development
sympathetic ganglion development
sympathetic nervous system development
sympathetic neuron projection extension
sympathetic neuron projection guidance
trigeminal ganglion development
trigeminal nerve structural organization
ventral trunk neural crest cell migration - Gene Ontology Biological Process:
- apoptotic process
axonal fasciculation
axon extension involved in axon guidance
axon guidance
axonogenesis involved in innervation
branchiomotor neuron axon guidance
dendrite morphogenesis
dichotomous subdivision of terminal units involved in salivary gland branching
facial nerve structural organization
facioacoustic ganglion development
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
negative regulation of axon extension involved in axon guidance
negative regulation of epithelial cell migration
nerve development
neural crest cell migration
neural crest cell migration involved in autonomic nervous system development
neural crest cell migration involved in sympathetic nervous system development
neuron migration
olfactory bulb development
positive regulation of male gonad development
positive regulation of neuron migration
regulation of axon extension involved in axon guidance
regulation of heart rate
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
sensory system development
sympathetic ganglion development
sympathetic nervous system development
sympathetic neuron projection extension
sympathetic neuron projection guidance
trigeminal ganglion development
trigeminal nerve structural organization
ventral trunk neural crest cell migration - Gene Ontology Molecular Function:
- chemorepellent activity
neuropilin binding
semaphorin receptor binding - Gene Ontology Cellular Component:
- axon
dendrite
extracellular region
extracellular space - Keywords:
- Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Glycoprotein
Hypogonadotropic hypogonadism
Immunoglobulin domain
Kallmann syndrome
Neurogenesis
Polymorphism
Reference proteome
Secreted
Signal