Names & Taxonomy
- Uniprot ID:
- Q14432
- Entry Name:
- PDE3A_HUMAN
- Status:
- reviewed
- Protein Names:
- cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)
- Gene Names:
- PDE3A
- Gene Names Primary:
- PDE3A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1141
- Sequence:
- MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
- Catalytic Activity:
- Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by cGMP.
- Active Site:
- ACT_SITE 752 752 Proton donor.
- Cross Reference Drug Bank:
- DB01223 DB01427 DB00261 DB00201 DB01166 DB04880 DB05266 DB00922 DB00235 DB01303 DB00277 DB08811
- Gene Ontology Go:
- cytosol
integral component of membrane
3',5'-cyclic-AMP phosphodiesterase activity
cAMP binding
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
metal ion binding
blood coagulation
cAMP catabolic process
cAMP-mediated signaling
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
cGMP-mediated signaling
diterpenoid metabolic process
lipid metabolic process
negative regulation of apoptotic process
negative regulation of vascular permeability
oocyte maturation
positive regulation of oocyte development
positive regulation of vascular permeability
regulation of meiotic nuclear division
response to cAMP
response to drug - Gene Ontology Biological Process:
- blood coagulation
cAMP catabolic process
cAMP-mediated signaling
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
cGMP-mediated signaling
diterpenoid metabolic process
lipid metabolic process
negative regulation of apoptotic process
negative regulation of vascular permeability
oocyte maturation
positive regulation of oocyte development
positive regulation of vascular permeability
regulation of meiotic nuclear division
response to cAMP
response to drug - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
cAMP binding
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
integral component of membrane - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Hydrolase
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
cAMP
cGMP