Names & Taxonomy
- Uniprot ID:
- Q14416
- Entry Name:
- GRM2_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 2 (mGluR2)
- Gene Names:
- GRM2 GPRC1B MGLUR2
- Gene Names Primary:
- GRM2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 872
- Sequence:
- MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
- Gene Ontology Go:
- axon
cell junction
dendrite
integral component of plasma membrane
intracellular
plasma membrane
presynaptic membrane
calcium channel regulator activity
G-protein coupled receptor activity
glutamate receptor activity
group II metabotropic glutamate receptor activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
glutamate secretion
negative regulation of adenylate cyclase activity
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
glutamate secretion
negative regulation of adenylate cyclase activity
synaptic transmission - Gene Ontology Molecular Function:
- calcium channel regulator activity
glutamate receptor activity
G-protein coupled receptor activity
group II metabotropic glutamate receptor activity - Gene Ontology Cellular Component:
- axon
cell junction
dendrite
integral component of plasma membrane
intracellular
plasma membrane
presynaptic membrane - Keywords:
- 3D-structure
Cell junction
Cell membrane
Cell projection
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Signal
Synapse
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q58DX5; Q9UMX0-2