Names & Taxonomy
- Uniprot ID:
- Q14181
- Entry Name:
- DPOA2_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)
- Gene Names:
- POLA2
- Gene Names Primary:
- POLA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 598
- Sequence:
- MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
- Cross Reference Drug Bank:
- DB00851
- Gene Ontology Go:
- alpha DNA polymerase:primase complex
cytoplasm
nucleoplasm
DNA binding
DNA-directed DNA polymerase activity
protein heterodimerization activity
DNA replication
DNA replication initiation
DNA strand elongation involved in DNA replication
G1/S transition of mitotic cell cycle
mitotic cell cycle
protein import into nucleus, translocation
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication - Gene Ontology Biological Process:
- DNA replication
DNA replication initiation
DNA strand elongation involved in DNA replication
G1/S transition of mitotic cell cycle
mitotic cell cycle
protein import into nucleus, translocation
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication - Gene Ontology Molecular Function:
- DNA binding
DNA-directed DNA polymerase activity
protein heterodimerization activity - Gene Ontology Cellular Component:
- alpha DNA polymerase:primase complex
cytoplasm
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
DNA replication
Nucleus
Phosphoprotein
Polymorphism
Reference proteome