Names & Taxonomy
- Uniprot ID:
- Q13639
- Entry Name:
- 5HT4R_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4)
- Gene Names:
- HTR4
- Gene Names Primary:
- HTR4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 388
- Sequence:
- MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Function
- Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
- Cross Reference Drug Bank:
- DB08810 DB00604 DB01049 DB01233 DB00904 DB06480
- Gene Ontology Go:
- cytoplasm
endosome
integral component of plasma membrane
membrane
plasma membrane
G-protein coupled serotonin receptor activity
identical protein binding
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
gamma-aminobutyric acid signaling pathway
regulation of appetite
serotonin receptor signaling pathway
synaptic transmission - Gene Ontology Biological Process:
- gamma-aminobutyric acid signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of appetite
serotonin receptor signaling pathway
synaptic transmission - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
identical protein binding - Gene Ontology Cellular Component:
- cytoplasm
endosome
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix