Names & Taxonomy
- Uniprot ID:
- Q13370
- Entry Name:
- PDE3B_HUMAN
- Status:
- reviewed
- Protein Names:
- cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)
- Gene Names:
- PDE3B
- Gene Names Primary:
- PDE3B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1112
- Sequence:
- MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEADEEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
- Catalytic Activity:
- Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by cGMP.
- Active Site:
- ACT_SITE 737 737 Proton donor.
- Cross Reference Drug Bank:
- DB00201
- Gene Ontology Go:
- cytosol
endoplasmic reticulum
Golgi apparatus
guanyl-nucleotide exchange factor complex
integral component of membrane
membrane
3',5'-cyclic-nucleotide phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
metal ion binding
protein kinase B binding
angiogenesis
blood coagulation
cAMP catabolic process
cellular response to insulin stimulus
insulin receptor signaling pathway
negative regulation of angiogenesis
negative regulation of cAMP-mediated signaling
negative regulation of cell adhesion
negative regulation of cell adhesion mediated by integrin
negative regulation of lipid catabolic process - Gene Ontology Biological Process:
- angiogenesis
blood coagulation
cAMP catabolic process
cellular response to insulin stimulus
insulin receptor signaling pathway
negative regulation of angiogenesis
negative regulation of cAMP-mediated signaling
negative regulation of cell adhesion
negative regulation of cell adhesion mediated by integrin
negative regulation of lipid catabolic process - Gene Ontology Molecular Function:
- 3',5'-cyclic-nucleotide phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
metal ion binding
protein kinase B binding - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum
Golgi apparatus
guanyl-nucleotide exchange factor complex
integral component of membrane
membrane - Keywords:
- 3D-structure
Alternative splicing
Angiogenesis
Complete proteome
Hydrolase
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
cAMP
cGMP - Interacts With:
- P48736; Q5UE93; O95398