Names & Taxonomy
- Uniprot ID:
- Q13258
- Entry Name:
- PD2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)
- Gene Names:
- PTGDR
- Gene Names Primary:
- PTGDR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 359
- Sequence:
- MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
- Cross Reference Drug Bank:
- DB00716
- Gene Ontology Go:
- integral component of membrane
plasma membrane
prostaglandin D receptor activity
prostaglandin J receptor activity
adenosine metabolic process
cellular response to prostaglandin D stimulus
G-protein coupled receptor signaling pathway
inflammatory response
male sex determination
sleep - Gene Ontology Biological Process:
- adenosine metabolic process
cellular response to prostaglandin D stimulus
G-protein coupled receptor signaling pathway
inflammatory response
male sex determination
sleep - Gene Ontology Molecular Function:
- prostaglandin D receptor activity
prostaglandin J receptor activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Asthma
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix