Names & Taxonomy

Uniprot ID:
Q13258
Entry Name:
PD2R_HUMAN
Status:
reviewed
Protein Names:
Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)
Gene Names:
PTGDR
Gene Names Primary:
PTGDR
Organism:
Homo sapiens (Human)

Structure

Length:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Cross Reference Drug Bank:
DB00716
Gene Ontology Go:
integral component of membrane
plasma membrane
prostaglandin D receptor activity
prostaglandin J receptor activity
adenosine metabolic process
cellular response to prostaglandin D stimulus
G-protein coupled receptor signaling pathway
inflammatory response
male sex determination
sleep
Gene Ontology Biological Process:
adenosine metabolic process
cellular response to prostaglandin D stimulus
G-protein coupled receptor signaling pathway
inflammatory response
male sex determination
sleep
Gene Ontology Molecular Function:
prostaglandin D receptor activity
prostaglandin J receptor activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Asthma
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
7642548 12508121 15489334 6302737 11082108 15496624