Names & Taxonomy
- Uniprot ID:
- Q13126
- Entry Name:
- MTAP_HUMAN
- Status:
- reviewed
- Protein Names:
- S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)
- Gene Names:
- MTAP MSAP
- Gene Names Primary:
- MTAP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 283
- Sequence:
- MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus
Function
- Function:
- Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
- Pathway:
- Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.
- Catalytic Activity:
- S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5 uM for S-methyl-5'-thioadenosine
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by 5'-methylthiotubercin and 5'-chloroformycin.
- Cross Reference Drug Bank:
- DB00173
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
phosphorylase activity
S-methyl-5-thioadenosine phosphorylase activity
cellular nitrogen compound metabolic process
L-methionine biosynthetic process from methylthioadenosine
methylation
nucleobase-containing compound metabolic process
polyamine metabolic process
purine ribonucleoside salvage
purine-containing compound salvage
response to testosterone
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
L-methionine biosynthetic process from methylthioadenosine
methylation
nucleobase-containing compound metabolic process
polyamine metabolic process
purine-containing compound salvage
purine ribonucleoside salvage
response to testosterone
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Molecular Function:
- phosphorylase activity
S-methyl-5-thioadenosine phosphorylase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Glycosyltransferase
Nucleus
Polymorphism
Purine salvage
Reference proteome
Transferase - Interacts With:
- Q9H3R5