Names & Taxonomy
- Uniprot ID:
- Q13002
- Entry Name:
- GRIK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
- Gene Names:
- GRIK2 GLUR6
- Gene Names Primary:
- GRIK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 908
- Sequence:
- MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).
- Cross Reference Drug Bank:
- DB01351 DB01352 DB00237 DB00241 DB01353 DB01354 DB01355 DB00849 DB00312 DB01174 DB00794 DB00418 DB00306 DB00599
- Gene Ontology Go:
- cell junction
dendrite cytoplasm
integral component of plasma membrane
kainate selective glutamate receptor complex
perikaryon
plasma membrane
postsynaptic density
postsynaptic membrane
presynaptic membrane
terminal bouton
extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity
behavioral fear response
cellular calcium ion homeostasis
excitatory postsynaptic potential
glutamate receptor signaling pathway
inhibitory postsynaptic potential
intracellular protein transport
modulation of synaptic transmission
negative regulation of neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
neuron apoptotic process
neuronal action potential
positive regulation of neuron apoptotic process
positive regulation of synaptic transmission
receptor clustering
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
synaptic transmission
synaptic transmission, glutamatergic
transport - Gene Ontology Biological Process:
- behavioral fear response
cellular calcium ion homeostasis
excitatory postsynaptic potential
glutamate receptor signaling pathway
inhibitory postsynaptic potential
intracellular protein transport
modulation of synaptic transmission
negative regulation of neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
neuronal action potential
neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of synaptic transmission
receptor clustering
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
synaptic transmission
synaptic transmission, glutamatergic
transport - Gene Ontology Molecular Function:
- extracellular-glutamate-gated ion channel activity
kainate selective glutamate receptor activity - Gene Ontology Cellular Component:
- cell junction
dendrite cytoplasm
integral component of plasma membrane
kainate selective glutamate receptor complex
perikaryon
plasma membrane
postsynaptic density
postsynaptic membrane
presynaptic membrane
terminal bouton - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Isopeptide bond
Ligand-gated ion channel
Membrane
Mental retardation
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
RNA editing
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Ubl conjugation