Names & Taxonomy

Uniprot ID:
Q12882
Entry Name:
DPYD_HUMAN
Status:
reviewed
Protein Names:
Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)
Gene Names:
DPYD
Gene Names Primary:
DPYD
Organism:
Homo sapiens (Human)

Structure

Length:
1025
Sequence:
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Pathway:
Amino-acid biosynthesis; beta-alanine biosynthesis.
Catalytic Activity:
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
Cofactor:
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; ; Note=Binds 2 FAD.;; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; ; Note=Binds 2 FMN.;; COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
Active Site:
ACT_SITE 671 671 Proton acceptor.
Cross Reference Drug Bank:
DB01101 DB03147 DB00544
Gene Ontology Go:
cytoplasm
cytosol
4 iron, 4 sulfur cluster binding
dihydropyrimidine dehydrogenase (NADP+) activity
flavin adenine dinucleotide binding
metal ion binding
NADP binding
protein homodimerization activity
beta-alanine biosynthetic process
nucleobase-containing small molecule metabolic process
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process
thymidine catabolic process
thymine catabolic process
uracil catabolic process
Gene Ontology Biological Process:
beta-alanine biosynthetic process
nucleobase-containing small molecule metabolic process
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process
thymidine catabolic process
thymine catabolic process
uracil catabolic process
Gene Ontology Molecular Function:
4 iron, 4 sulfur cluster binding
dihydropyrimidine dehydrogenase (NADP+) activity
flavin adenine dinucleotide binding
metal ion binding
NADP binding
protein homodimerization activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
Keywords:
4Fe-4S
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
FAD
FMN
Flavoprotein
Iron
Iron-sulfur
Metal-binding
NADP
Nucleotide-binding
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Interacts With:
Q9HD26; Q9BS40

Publication

PubMed ID:
8083224 9135003 9464498 14702039 16710414 15489334 8892022 9170156 1512248 19608861 22814378 24275569 9439663 9266349 9472650 9723824 18987736