Names & Taxonomy
- Uniprot ID:
- Q12882
- Entry Name:
- DPYD_HUMAN
- Status:
- reviewed
- Protein Names:
- Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)
- Gene Names:
- DPYD
- Gene Names Primary:
- DPYD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1025
- Sequence:
- MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
- Pathway:
- Amino-acid biosynthesis; beta-alanine biosynthesis.
- Catalytic Activity:
- 5,6-dihydrouracil + NADP(+) = uracil + NADPH.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; ; Note=Binds 2 FAD.;; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; ; Note=Binds 2 FMN.;; COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
- Active Site:
- ACT_SITE 671 671 Proton acceptor.
- Cross Reference Drug Bank:
- DB01101 DB03147 DB00544
- Gene Ontology Go:
- cytoplasm
cytosol
4 iron, 4 sulfur cluster binding
dihydropyrimidine dehydrogenase (NADP+) activity
flavin adenine dinucleotide binding
metal ion binding
NADP binding
protein homodimerization activity
beta-alanine biosynthetic process
nucleobase-containing small molecule metabolic process
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process
thymidine catabolic process
thymine catabolic process
uracil catabolic process - Gene Ontology Biological Process:
- beta-alanine biosynthetic process
nucleobase-containing small molecule metabolic process
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process
thymidine catabolic process
thymine catabolic process
uracil catabolic process - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
dihydropyrimidine dehydrogenase (NADP+) activity
flavin adenine dinucleotide binding
metal ion binding
NADP binding
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 4Fe-4S
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
FAD
FMN
Flavoprotein
Iron
Iron-sulfur
Metal-binding
NADP
Nucleotide-binding
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Repeat - Interacts With:
- Q9HD26; Q9BS40