Names & Taxonomy
- Uniprot ID:
- Q12879
- Entry Name:
- NMDE1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
- Gene Names:
- GRIN2A NMDAR2A
- Gene Names Primary:
- GRIN2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1464
- Sequence:
- MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
- Cross Reference Drug Bank:
- DB00659 DB06151 DB00289 DB00949 DB00996 DB00145 DB01159 DB06738 DB01043 DB04896 DB00312 DB00454 DB01174 DB00418
- Gene Ontology Go:
- cell junction
cell surface
endoplasmic reticulum
integral component of plasma membrane
neuron projection
neuronal postsynaptic density
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic membrane
presynaptic membrane
synaptic vesicle
calcium channel activity
extracellular-glutamate-gated ion channel activity
NMDA glutamate receptor activity
zinc ion binding
activation of MAPKK activity
axon guidance
directional locomotion
dopamine metabolic process
epidermal growth factor receptor signaling pathway
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glutamate receptor signaling pathway
innate immune response
insulin receptor signaling pathway
learning or memory
long-term synaptic potentiation
MAPK cascade
memory
negative regulation of protein catabolic process
neurotrophin TRK receptor signaling pathway
positive regulation of apoptotic process
positive regulation of long-term synaptic potentiation
protein localization
Ras protein signal transduction
regulation of sensory perception of pain
response to amphetamine
response to drug
response to ethanol
response to wounding
sensory perception of pain
serotonin metabolic process
sleep
small GTPase mediated signal transduction
startle response
synaptic transmission
transport
vascular endothelial growth factor receptor signaling pathway
visual learning - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
directional locomotion
dopamine metabolic process
epidermal growth factor receptor signaling pathway
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
glutamate receptor signaling pathway
innate immune response
insulin receptor signaling pathway
learning or memory
long-term synaptic potentiation
MAPK cascade
memory
negative regulation of protein catabolic process
neurotrophin TRK receptor signaling pathway
positive regulation of apoptotic process
positive regulation of long-term synaptic potentiation
protein localization
Ras protein signal transduction
regulation of sensory perception of pain
response to amphetamine
response to drug
response to ethanol
response to wounding
sensory perception of pain
serotonin metabolic process
sleep
small GTPase mediated signal transduction
startle response
synaptic transmission
transport
vascular endothelial growth factor receptor signaling pathway
visual learning - Gene Ontology Molecular Function:
- calcium channel activity
extracellular-glutamate-gated ion channel activity
NMDA glutamate receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- cell junction
cell surface
endoplasmic reticulum
integral component of plasma membrane
neuronal postsynaptic density
neuron projection
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic membrane
presynaptic membrane
synaptic vesicle - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell junction
Cell membrane
Chromosomal rearrangement
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Magnesium
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Zinc - Interacts With:
- Q62936; P78352; P31016