Names & Taxonomy
- Uniprot ID:
- Q10981
- Entry Name:
- FUT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se)
- Gene Names:
- FUT2 SEC2
- Gene Names Primary:
- FUT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 343
- Sequence:
- MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Function
- Function:
- Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
- Gene Ontology Go:
- extracellular exosome
Golgi apparatus
Golgi cisterna membrane
integral component of membrane
fucosyltransferase activity
galactoside 2-alpha-L-fucosyltransferase activity
carbohydrate metabolic process
fucosylation
L-fucose catabolic process
protein glycosylation - Gene Ontology Biological Process:
- carbohydrate metabolic process
fucosylation
L-fucose catabolic process
protein glycosylation - Gene Ontology Molecular Function:
- fucosyltransferase activity
galactoside 2-alpha-L-fucosyltransferase activity - Gene Ontology Cellular Component:
- extracellular exosome
Golgi apparatus
Golgi cisterna membrane
integral component of membrane - Keywords:
- Alternative initiation
Blood group antigen
Complete proteome
Glycoprotein
Glycosyltransferase
Golgi apparatus
Membrane
Polymorphism
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix