Names & Taxonomy
- Uniprot ID:
- Q09428
- Entry Name:
- ABCC8_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1)
- Gene Names:
- ABCC8 HRINS SUR SUR1
- Gene Names Primary:
- ABCC8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1581
- Sequence:
- MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRADK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
- Cross Reference Drug Bank:
- DB00171 DB00672 DB01120 DB00222 DB01067 DB01251 DB01016 DB01382 DB01252 DB00731 DB00912 DB01124
- Gene Ontology Go:
- plasma membrane
sarcolemma
synaptic vesicle membrane
voltage-gated potassium channel complex
ATP binding
ATPase activity, coupled to transmembrane movement of substances
ion channel binding
potassium channel activity
sulfonylurea receptor activity
cellular response to organic substance
energy reserve metabolic process
negative regulation of insulin secretion
positive regulation of potassium ion transport
potassium ion transmembrane transport
potassium ion transport
regulation of insulin secretion
response to drug
response to insulin
response to lipopolysaccharide
response to pH
response to zinc ion
small molecule metabolic process
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- cellular response to organic substance
energy reserve metabolic process
negative regulation of insulin secretion
positive regulation of potassium ion transport
potassium ion transmembrane transport
potassium ion transport
regulation of insulin secretion
response to drug
response to insulin
response to lipopolysaccharide
response to pH
response to zinc ion
small molecule metabolic process
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- ATPase activity, coupled to transmembrane movement of substances
ATP binding
ion channel binding
potassium channel activity
sulfonylurea receptor activity - Gene Ontology Cellular Component:
- plasma membrane
sarcolemma
synaptic vesicle membrane
voltage-gated potassium channel complex - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Diabetes mellitus
Disease mutation
Glycoprotein
Membrane
Nucleotide-binding
Polymorphism
Receptor
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Publication
- PubMed ID:
- 21671119 16554811 7716548 10506167 10204114 10338089 8751851 8635661 8923011 8650576 9519757 9568693 9648840 9618169 9769320 10334322 10447255 10202168 10615958 11018078 11226335 11867634 12364426 12941782 15356046 15579781 15807877 15562009 16613899 16429405 16357843 16885549 17668386 17213273 24814349 25720052