Names & Taxonomy
- Uniprot ID:
- Q09013
- Entry Name:
- DMPK_HUMAN
- Status:
- reviewed
- Protein Names:
- Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase)
- Gene Names:
- DMPK DM1PK MDPK
- Gene Names Primary:
- DMPK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 629
- Sequence:
- MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G-protein second messengers.
- Active Site:
- ACT_SITE 195 195 Proton acceptor.
- Gene Ontology Go:
- cytosol
endoplasmic reticulum membrane
integral component of mitochondrial outer membrane
nuclear membrane
nuclear outer membrane
plasma membrane
sarcoplasmic reticulum membrane
ATP binding
metal ion binding
myosin phosphatase regulator activity
protein serine/threonine kinase activity
cardiac conduction
cellular calcium ion homeostasis
muscle cell apoptotic process
nuclear envelope organization
peptidyl-serine phosphorylation
protein phosphorylation
regulation of cardiac conduction
regulation of catalytic activity
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
regulation of heart contraction
regulation of myotube differentiation
regulation of skeletal muscle contraction by calcium ion signaling
regulation of sodium ion transport
regulation of synapse structural plasticity - Gene Ontology Biological Process:
- cardiac conduction
cellular calcium ion homeostasis
muscle cell apoptotic process
nuclear envelope organization
peptidyl-serine phosphorylation
protein phosphorylation
regulation of cardiac conduction
regulation of catalytic activity
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
regulation of heart contraction
regulation of myotube differentiation
regulation of skeletal muscle contraction by calcium ion signaling
regulation of sodium ion transport
regulation of synapse structural plasticity - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
myosin phosphatase regulator activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum membrane
integral component of mitochondrial outer membrane
nuclear membrane
nuclear outer membrane
plasma membrane
sarcoplasmic reticulum membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cataract
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Endoplasmic reticulum
Kinase
Magnesium
Membrane
Metal-binding
Mitochondrion
Mitochondrion outer membrane
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Sarcoplasmic reticulum
Serine/threonine-protein kinase
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- P26678