Names & Taxonomy
- Uniprot ID:
- Q08499
- Entry Name:
- PDE4D_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43)
- Gene Names:
- PDE4D DPDE3
- Gene Names Primary:
- PDE4D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 809
- Sequence:
- MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
- Catalytic Activity:
- Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by rolipram. Activated by phosphatidic acid.
- Active Site:
- ACT_SITE 462 462 Proton donor.
- Cross Reference Drug Bank:
- DB00131 DB05676 DB00201 DB00651 DB05266 DB01088 DB00920 DB01656
- Gene Ontology Go:
- apical plasma membrane
calcium channel complex
centrosome
cytosol
membrane
voltage-gated calcium channel complex
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
ATPase binding
beta-2 adrenergic receptor binding
cAMP binding
drug binding
enzyme binding
ion channel binding
metal ion binding
scaffold protein binding
ubiquitin protein ligase binding
adrenergic receptor signaling pathway
adrenergic receptor signaling pathway involved in positive regulation of heart rate
aging
cAMP catabolic process
cAMP-mediated signaling
cellular response to cAMP
cellular response to epinephrine stimulus
cellular response to lipopolysaccharide
establishment of endothelial barrier
multicellular organism growth
negative regulation of heart contraction
negative regulation of peptidyl-serine phosphorylation
negative regulation of relaxation of cardiac muscle
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
regulation of cAMP metabolic process
regulation of cardiac muscle cell contraction
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of heart rate
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of ryanodine-sensitive calcium-release channel activity
smooth muscle contraction
T cell receptor signaling pathway - Gene Ontology Biological Process:
- adrenergic receptor signaling pathway
adrenergic receptor signaling pathway involved in positive regulation of heart rate
aging
cAMP catabolic process
cAMP-mediated signaling
cellular response to cAMP
cellular response to epinephrine stimulus
cellular response to lipopolysaccharide
establishment of endothelial barrier
multicellular organism growth
negative regulation of heart contraction
negative regulation of peptidyl-serine phosphorylation
negative regulation of relaxation of cardiac muscle
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
regulation of cAMP metabolic process
regulation of cardiac muscle cell contraction
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of heart rate
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of ryanodine-sensitive calcium-release channel activity
smooth muscle contraction
T cell receptor signaling pathway - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
ATPase binding
beta-2 adrenergic receptor binding
cAMP binding
drug binding
enzyme binding
ion channel binding
metal ion binding
scaffold protein binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- apical plasma membrane
calcium channel complex
centrosome
cytosol
membrane
voltage-gated calcium channel complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Hydrolase
Isopeptide bond
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Ubl conjugation
cAMP - Interacts With:
- P26769; P38432; Q0D2H9; Q08AF8; P43360; Q13077; Q8IUH5
Publication
- PubMed ID:
- 8413254 8797812 8125310 9371713 10913353 12834813 14517540 15489334 12193273 14500724 15131123 17081983 17006457 17244609 18088087 18669648 20196770 20068231 21406692 12387865 14609333 12842049 14668322 15003452 15260978 15576036 15685167 16539372 17727341 17900862 17582435 22464250 22464252 23043190 23033274