Names & Taxonomy
- Uniprot ID:
- Q08357
- Entry Name:
- S20A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)
- Gene Names:
- SLC20A2 GLVR2 PIT2
- Gene Names Primary:
- SLC20A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 652
- Sequence:
- MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
membrane
plasma membrane
inorganic phosphate transmembrane transporter activity
receptor activity
sodium:inorganic phosphate symporter activity
sodium:phosphate symporter activity
virus receptor activity
ion transport
phosphate ion transmembrane transport
sodium ion transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- ion transport
phosphate ion transmembrane transport
sodium ion transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- inorganic phosphate transmembrane transporter activity
receptor activity
sodium:inorganic phosphate symporter activity
sodium:phosphate symporter activity
virus receptor activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Ion transport
Membrane
Phosphate transport
Phosphoprotein
Receptor
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport