Names & Taxonomy
- Uniprot ID:
- Q08209
- Entry Name:
- PP2BA_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform)
- Gene Names:
- PPP3CA CALNA CNA
- Gene Names Primary:
- PPP3CA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 521
- Sequence:
- MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
- Catalytic Activity:
- -serine/threonine phosphate + H(2)O = -serine/threonine + phosphate.
- Cofactor:
- COFACTOR: Name=Fe(3+); Xref=ChEBI:CHEBI:29034; ; Note=Binds 1 Fe(3+) ion per subunit.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per subunit.;
- Active Site:
- ACT_SITE 151 151 Proton donor.
- Gene Ontology Go:
- calcineurin complex
cytoplasm
cytosol
mitochondrion
nucleoplasm
postsynapse
sarcolemma
Z disc
calcium ion binding
calmodulin binding
calmodulin-dependent protein phosphatase activity
drug binding
enzyme binding
protein dimerization activity
protein serine/threonine phosphatase activity
calcineurin-NFAT signaling cascade
calcium ion transport
cardiac muscle hypertrophy in response to stress
cellular response to drug
cellular response to glucose stimulus
dephosphorylation
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
modulation of synaptic transmission
multicellular organismal response to stress
negative regulation of chromatin binding
negative regulation of dendrite morphogenesis
negative regulation of insulin secretion
positive regulation of cardiac muscle hypertrophy in response to stress
positive regulation of NFAT protein import into nucleus
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
protein import into nucleus
response to amphetamine
response to calcium ion
skeletal muscle fiber development
stimulatory C-type lectin receptor signaling pathway
T cell activation
transition between fast and slow fiber - Gene Ontology Biological Process:
- calcineurin-NFAT signaling cascade
calcium ion transport
cardiac muscle hypertrophy in response to stress
cellular response to drug
cellular response to glucose stimulus
dephosphorylation
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
modulation of synaptic transmission
multicellular organismal response to stress
negative regulation of chromatin binding
negative regulation of dendrite morphogenesis
negative regulation of insulin secretion
positive regulation of cardiac muscle hypertrophy in response to stress
positive regulation of NFAT protein import into nucleus
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
protein import into nucleus
response to amphetamine
response to calcium ion
skeletal muscle fiber development
stimulatory C-type lectin receptor signaling pathway
T cell activation
transition between fast and slow fiber - Gene Ontology Molecular Function:
- calcium ion binding
calmodulin binding
calmodulin-dependent protein phosphatase activity
drug binding
enzyme binding
protein dimerization activity
protein serine/threonine phosphatase activity - Gene Ontology Cellular Component:
- calcineurin complex
cytoplasm
cytosol
mitochondrion
nucleoplasm
postsynapse
sarcolemma
Z disc - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Calmodulin-binding
Cell membrane
Complete proteome
Hydrolase
Iron
Membrane
Metal-binding
Nitration
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Zinc - Interacts With:
- R4GN89; Q8VHW5; P62993; P63098; P54578