Names & Taxonomy

Uniprot ID:
Q07869
Entry Name:
PPARA_HUMAN
Status:
reviewed
Protein Names:
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene Names:
PPARA NR1C1 PPAR
Gene Names Primary:
PPARA
Organism:
Homo sapiens (Human)

Structure

Length:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus.

Function

Function:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Cross Reference Drug Bank:
DB01393 DB00636 DB01039 DB01241 DB00328
Gene Ontology Go:
nucleoplasm
nucleus
DNA binding
drug binding
lipid binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
ubiquitin conjugating enzyme binding
zinc ion binding
behavioral response to nicotine
cellular lipid metabolic process
circadian regulation of gene expression
circadian rhythm
enamel mineralization
epidermis development
fatty acid metabolic process
fatty acid transport
gene expression
heart development
lipid metabolic process
lipoprotein metabolic process
negative regulation of appetite
negative regulation of blood pressure
negative regulation of cholesterol storage
negative regulation of glycolytic process
negative regulation of inflammatory response
negative regulation of leukocyte cell-cell adhesion
negative regulation of macrophage derived foam cell differentiation
negative regulation of neuron death
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of protein binding
negative regulation of receptor biosynthetic process
negative regulation of sequestering of triglyceride
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription regulatory region DNA binding
positive regulation of fatty acid beta-oxidation
positive regulation of fatty acid oxidation
positive regulation of gluconeogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
regulation of circadian rhythm
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
response to hypoxia
response to insulin
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
wound healing
Gene Ontology Biological Process:
behavioral response to nicotine
cellular lipid metabolic process
circadian regulation of gene expression
circadian rhythm
enamel mineralization
epidermis development
fatty acid metabolic process
fatty acid transport
gene expression
heart development
lipid metabolic process
lipoprotein metabolic process
negative regulation of appetite
negative regulation of blood pressure
negative regulation of cholesterol storage
negative regulation of glycolytic process
negative regulation of inflammatory response
negative regulation of leukocyte cell-cell adhesion
negative regulation of macrophage derived foam cell differentiation
negative regulation of neuron death
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of protein binding
negative regulation of receptor biosynthetic process
negative regulation of sequestering of triglyceride
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription regulatory region DNA binding
positive regulation of fatty acid beta-oxidation
positive regulation of fatty acid oxidation
positive regulation of gluconeogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
regulation of circadian rhythm
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
response to hypoxia
response to insulin
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
wound healing
Gene Ontology Molecular Function:
DNA binding
drug binding
lipid binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
ubiquitin conjugating enzyme binding
zinc ion binding
Gene Ontology Cellular Component:
nucleoplasm
nucleus
Keywords:
3D-structure
Activator
Alternative splicing
Biological rhythms
Complete proteome
DNA-binding
Lipid-binding
Metal-binding
Nucleus
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger
Interacts With:
Q3L8U1-3; P62993; O75376

Publication

PubMed ID:
7684926 7981125 8993548 18619963 19263263 15461802 14702039 10591208 7629123 9238002 9556573 10195690 10681503 11915042 12955147 21047783 24043310 11698662 11587644 11845213 17157019 17243659 19622862 19349176 19116277