Names & Taxonomy
- Uniprot ID:
- Q07817
- Entry Name:
- B2CL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
- Gene Names:
- BCL2L1 BCL2L BCLX
- Gene Names Primary:
- BCL2L1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 233
- Sequence:
- MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Bcl-X(L): Mitochondrion inner membrane
Function
- Function:
- Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
- Gene Ontology Go:
- Bcl-2 family protein complex
cell junction
centrosome
cytoplasm
cytosol
integral component of membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial outer membrane
mitochondrion
nuclear membrane
synaptic vesicle membrane
BH3 domain binding
identical protein binding
protein heterodimerization activity
protein homodimerization activity
protein kinase binding
apoptotic mitochondrial changes
apoptotic process
apoptotic process in bone marrow
cell proliferation
cellular process regulating host cell cycle in response to virus
cellular response to alkaloid
cellular response to amino acid stimulus
cellular response to gamma radiation
cytokinesis
endocytosis
extrinsic apoptotic signaling pathway in absence of ligand
fertilization
germ cell development
growth
hepatocyte apoptotic process
in utero embryonic development
innate immune response
intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
male gonad development
mitochondrion morphogenesis
mitotic cell cycle checkpoint
negative regulation of anoikis
negative regulation of apoptotic process
negative regulation of autophagy
negative regulation of establishment of protein localization to plasma membrane
negative regulation of execution phase of apoptosis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of neuron apoptotic process
negative regulation of release of cytochrome c from mitochondria
neuron apoptotic process
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
ovarian follicle development
positive regulation of cell proliferation
positive regulation of intrinsic apoptotic signaling pathway
programmed cell death
regulation of mitochondrial membrane permeability
regulation of mitochondrial membrane potential
release of cytochrome c from mitochondria
response to cycloheximide
response to cytokine
spermatogenesis
suppression by virus of host apoptotic process - Gene Ontology Biological Process:
- apoptotic mitochondrial changes
apoptotic process
apoptotic process in bone marrow
cell proliferation
cellular process regulating host cell cycle in response to virus
cellular response to alkaloid
cellular response to amino acid stimulus
cellular response to gamma radiation
cytokinesis
endocytosis
extrinsic apoptotic signaling pathway in absence of ligand
fertilization
germ cell development
growth
hepatocyte apoptotic process
innate immune response
intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
in utero embryonic development
male gonad development
mitochondrion morphogenesis
mitotic cell cycle checkpoint
negative regulation of anoikis
negative regulation of apoptotic process
negative regulation of autophagy
negative regulation of establishment of protein localization to plasma membrane
negative regulation of execution phase of apoptosis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of neuron apoptotic process
negative regulation of release of cytochrome c from mitochondria
neuron apoptotic process
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
ovarian follicle development
positive regulation of cell proliferation
positive regulation of intrinsic apoptotic signaling pathway
programmed cell death
regulation of mitochondrial membrane permeability
regulation of mitochondrial membrane potential
release of cytochrome c from mitochondria
response to cycloheximide
response to cytokine
spermatogenesis
suppression by virus of host apoptotic process - Gene Ontology Molecular Function:
- BH3 domain binding
identical protein binding
protein heterodimerization activity
protein homodimerization activity
protein kinase binding - Gene Ontology Cellular Component:
- Bcl-2 family protein complex
cell junction
centrosome
cytoplasm
cytosol
integral component of membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial outer membrane
mitochondrion
nuclear membrane
synaptic vesicle membrane - Keywords:
- 3D-structure
Alternative splicing
Apoptosis
Cell junction
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Endocytosis
Membrane
Mitochondrion
Mitochondrion inner membrane
Mitochondrion outer membrane
Nucleus
Phosphoprotein
Reference proteome
Synapse
Transmembrane
Transmembrane helix - Interacts With:
- Itself; Q92934; Q61337; Q16611; Q07812; Q9BXH1; Q99ML1; O43521; O43521-1; Q14457; P55957; Q13323; Q96LC9; Q7L3V2; P30429-2; P10909-4; P99999; O00198; Q9C000; O15304; O15304-1; Q9H2V7; P04637; P02340; Q13625; Q86Y07-1