Names & Taxonomy
- Uniprot ID:
- Q07075
- Entry Name:
- AMPE_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)
- Gene Names:
- ENPEP
- Gene Names Primary:
- ENPEP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 957
- Sequence:
- MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type II membrane protein.
Function
- Function:
- Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
- Catalytic Activity:
- Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 394 394 Proton acceptor.
- Gene Ontology Go:
- apical part of cell
apical plasma membrane
brush border
cytoplasmic vesicle
external side of plasma membrane
extracellular exosome
integral component of plasma membrane
lysosomal membrane
plasma membrane
aminopeptidase activity
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
zinc ion binding
angiogenesis
angiotensin catabolic process in blood
angiotensin maturation
cell migration
cell proliferation
cell-cell signaling
cellular protein metabolic process
glomerulus development
peptide catabolic process
regulation of systemic arterial blood pressure by renin-angiotensin - Gene Ontology Biological Process:
- angiogenesis
angiotensin catabolic process in blood
angiotensin maturation
cell-cell signaling
cell migration
cell proliferation
cellular protein metabolic process
glomerulus development
peptide catabolic process
regulation of systemic arterial blood pressure by renin-angiotensin - Gene Ontology Molecular Function:
- aminopeptidase activity
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
zinc ion binding - Gene Ontology Cellular Component:
- apical part of cell
apical plasma membrane
brush border
cytoplasmic vesicle
external side of plasma membrane
extracellular exosome
integral component of plasma membrane
lysosomal membrane
plasma membrane - Keywords:
- 3D-structure
Aminopeptidase
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc