Names & Taxonomy
- Uniprot ID:
- Q06609
- Entry Name:
- RAD51_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)
- Gene Names:
- RAD51 RAD51A RECA
- Gene Names Primary:
- RAD51
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 339
- Sequence:
- MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
- Gene Ontology Go:
- chromatin
condensed chromosome
condensed nuclear chromosome
cytoplasm
lateral element
microtubule organizing center
mitochondrial matrix
mitochondrion
nuclear chromosome
nuclear chromosome, telomeric region
nucleolus
nucleoplasm
nucleus
perinuclear region of cytoplasm
PML body
site of double-strand break
ATP binding
chromatin binding
DNA polymerase binding
double-stranded DNA binding
four-way junction DNA binding
identical protein binding
protein C-terminus binding
recombinase activity
single-stranded DNA binding
single-stranded DNA-dependent ATPase activity
cellular response to camptothecin
cellular response to cisplatin
cellular response to DNA damage stimulus
cellular response to gamma radiation
cellular response to hydroxyurea
cellular response to ionizing radiation
chromosome organization involved in meiotic cell cycle
DNA recombinase assembly
DNA recombination
DNA repair
DNA unwinding involved in DNA replication
double-strand break repair
double-strand break repair via homologous recombination
double-strand break repair via synthesis-dependent strand annealing
homologous recombination-dependent replication fork processing
meiotic nuclear division
mitotic recombination
positive regulation of DNA ligation
protein homooligomerization
reciprocal meiotic recombination
regulation of double-strand break repair via homologous recombination
regulation of protein phosphorylation
replication fork processing
replication-born double-strand break repair via sister chromatid exchange
response to drug
response to etoposide
response to toxic substance
response to X-ray
strand invasion
telomere maintenance via recombination
telomere maintenance via telomere lengthening - Gene Ontology Biological Process:
- cellular response to camptothecin
cellular response to cisplatin
cellular response to DNA damage stimulus
cellular response to gamma radiation
cellular response to hydroxyurea
cellular response to ionizing radiation
chromosome organization involved in meiotic cell cycle
DNA recombinase assembly
DNA recombination
DNA repair
DNA unwinding involved in DNA replication
double-strand break repair
double-strand break repair via homologous recombination
double-strand break repair via synthesis-dependent strand annealing
homologous recombination-dependent replication fork processing
meiotic nuclear division
mitotic recombination
positive regulation of DNA ligation
protein homooligomerization
reciprocal meiotic recombination
regulation of double-strand break repair via homologous recombination
regulation of protein phosphorylation
replication-born double-strand break repair via sister chromatid exchange
replication fork processing
response to drug
response to etoposide
response to toxic substance
response to X-ray
strand invasion
telomere maintenance via recombination
telomere maintenance via telomere lengthening - Gene Ontology Molecular Function:
- ATP binding
chromatin binding
DNA polymerase binding
double-stranded DNA binding
four-way junction DNA binding
identical protein binding
protein C-terminus binding
recombinase activity
single-stranded DNA binding
single-stranded DNA-dependent ATPase activity - Gene Ontology Cellular Component:
- chromatin
condensed chromosome
condensed nuclear chromosome
cytoplasm
lateral element
microtubule organizing center
mitochondrial matrix
mitochondrion
nuclear chromosome
nuclear chromosome, telomeric region
nucleolus
nucleoplasm
nucleus
perinuclear region of cytoplasm
PML body
site of double-strand break - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
DNA damage
DNA recombination
DNA repair
DNA-binding
Disease mutation
Isopeptide bond
Mitochondrion
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation - Interacts With:
- Itself; P51587; O14757; Q96KN1; Q13007; P11245; Q86YC2; Q96B01-2; Q96B01-3; O43502; P43351; Q6NVH7; P04637; Q9BZ95; O43542
Publication
- PubMed ID:
- 8358431 8479919 10493508 11535547 18417535 14702039 16572171 15489334 7988572 9321665 9396801 9192668 9461559 10851248 12205100 11842113 12427746 14580352 16215984 15665856 16990250 18449195 19783859 20348101 20413593 20705237 20231364 20154705 20871615 21276791 21252223 21965664 22305526 22153967 22814378 24013206 23393192 24141787 23754376 23509288 25642963 10390347 12442171 10807537