Names & Taxonomy

Uniprot ID:
Q06124
Entry Name:
PTN11_HUMAN
Status:
reviewed
Protein Names:
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene Names:
PTPN11 PTP2C SHPTP2
Gene Names Primary:
PTPN11
Organism:
Homo sapiens (Human)

Structure

Length:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 463 463 Phosphocysteine intermediate.
Gene Ontology Go:
cytoplasm
cytosol
mitochondrion
nucleus
protein complex
insulin receptor binding
non-membrane spanning protein tyrosine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
SH3/SH2 adaptor activity
abortive mitotic cell cycle
activation of MAPK activity
atrioventricular canal development
axon guidance
Bergmann glial cell differentiation
blood coagulation
brain development
cerebellar cortex formation
cytokine-mediated signaling pathway
DNA damage checkpoint
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
ERBB signaling pathway
face morphogenesis
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
genitalia development
glucose homeostasis
heart development
homeostasis of number of cells within a tissue
hormone metabolic process
hormone-mediated signaling pathway
innate immune response
inner ear development
insulin receptor signaling pathway
integrin-mediated signaling pathway
interferon-gamma-mediated signaling pathway
intestinal epithelial cell migration
leukocyte migration
megakaryocyte development
microvillus organization
multicellular organism growth
multicellular organismal reproductive process
negative regulation of cell adhesion mediated by integrin
negative regulation of cortisol secretion
negative regulation of growth hormone secretion
negative regulation of insulin secretion
neurotrophin TRK receptor signaling pathway
organ growth
peptidyl-tyrosine dephosphorylation
phosphatidylinositol-mediated signaling
platelet activation
platelet formation
platelet-derived growth factor receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of glucose import in response to insulin stimulus
positive regulation of hormone secretion
positive regulation of mitotic cell cycle
regulation of cell adhesion mediated by integrin
regulation of interferon-gamma-mediated signaling pathway
regulation of multicellular organism growth
regulation of protein complex assembly
regulation of protein export from nucleus
regulation of type I interferon-mediated signaling pathway
T cell costimulation
triglyceride metabolic process
type I interferon signaling pathway
Gene Ontology Biological Process:
abortive mitotic cell cycle
activation of MAPK activity
atrioventricular canal development
axon guidance
Bergmann glial cell differentiation
blood coagulation
brain development
cerebellar cortex formation
cytokine-mediated signaling pathway
DNA damage checkpoint
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
ERBB signaling pathway
face morphogenesis
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
genitalia development
glucose homeostasis
heart development
homeostasis of number of cells within a tissue
hormone-mediated signaling pathway
hormone metabolic process
innate immune response
inner ear development
insulin receptor signaling pathway
integrin-mediated signaling pathway
interferon-gamma-mediated signaling pathway
intestinal epithelial cell migration
leukocyte migration
megakaryocyte development
microvillus organization
multicellular organismal reproductive process
multicellular organism growth
negative regulation of cell adhesion mediated by integrin
negative regulation of cortisol secretion
negative regulation of growth hormone secretion
negative regulation of insulin secretion
neurotrophin TRK receptor signaling pathway
organ growth
peptidyl-tyrosine dephosphorylation
phosphatidylinositol-mediated signaling
platelet activation
platelet-derived growth factor receptor signaling pathway
platelet formation
positive regulation of ERK1 and ERK2 cascade
positive regulation of glucose import in response to insulin stimulus
positive regulation of hormone secretion
positive regulation of mitotic cell cycle
regulation of cell adhesion mediated by integrin
regulation of interferon-gamma-mediated signaling pathway
regulation of multicellular organism growth
regulation of protein complex assembly
regulation of protein export from nucleus
regulation of type I interferon-mediated signaling pathway
T cell costimulation
triglyceride metabolic process
type I interferon signaling pathway
Gene Ontology Molecular Function:
insulin receptor binding
non-membrane spanning protein tyrosine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
SH3/SH2 adaptor activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
mitochondrion
nucleus
protein complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Deafness
Disease mutation
Hydrolase
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
SH2 domain
Interacts With:
P10275; P32239; Q9BZW8; P20138; Q08345; P68105; Q71V39; P04626; P17948; Q13480; Q9UQC2; P62993; P08069; P06213; P35568; P35570; P43628; P10721; P08581; O95297; P09619; P16284; P49023; P49247; P97710; Q13049

Publication

PubMed ID:
1281790 1280823 8216283 7681589 7681217 14702039 15489334 7691811 8041791 8810330 9062191 9600074 10068651 10209036 10655584 10681522 11162587 11389028 11414741 11433379 12972546 14597715 15526160 15102829 15592455 16956752 16885344 17213291 18829466 18559669 18604210 19413330 19509291 19342684 19690332 20494825 20577567 20068231 21269460 24275569 9491886 19167335 20170098 11704759 11992261 12058348 12325025 12161469 12529711 12634870 12739139 14961557 12960218 12717436 15384080 15389709 15520399 15121796 15948193 15690106 16679933 19020799 24891296