Names & Taxonomy

Uniprot ID:
Q05901
Entry Name:
ACHB3_HUMAN
Status:
reviewed
Protein Names:
Neuronal acetylcholine receptor subunit beta-3
Gene Names:
CHRNB3
Gene Names Primary:
CHRNB3
Organism:
Homo sapiens (Human)

Structure

Length:
458
Sequence:
MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cross Reference Drug Bank:
DB00898 DB00674 DB00184
Gene Ontology Go:
acetylcholine-gated channel complex
cell junction
integral component of membrane
neuron projection
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine-activated cation-selective channel activity
channel activity
drug binding
cation transmembrane transport
chemical synaptic transmission, postsynaptic
neuromuscular synaptic transmission
protein heterooligomerization
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic
transmembrane transport
transport
Gene Ontology Biological Process:
cation transmembrane transport
chemical synaptic transmission, postsynaptic
neuromuscular synaptic transmission
protein heterooligomerization
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic
transmembrane transport
transport
Gene Ontology Molecular Function:
acetylcholine-activated cation-selective channel activity
acetylcholine binding
channel activity
drug binding
Gene Ontology Cellular Component:
acetylcholine-gated channel complex
cell junction
integral component of membrane
neuron projection
plasma membrane
postsynaptic membrane
Keywords:
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8906617 9009220 15489334 7690916