Names & Taxonomy
- Uniprot ID:
- Q05586
- Entry Name:
- NMDZ1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
- Gene Names:
- GRIN1 NMDAR1
- Gene Names Primary:
- GRIN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 938
- Sequence:
- MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
- Cross Reference Drug Bank:
- DB00659 DB06151 DB00289 DB00996 DB08954 DB06738 DB01043 DB04896 DB01173 DB00312 DB00454 DB01174 DB00418
- Gene Ontology Go:
- cell junction
cell surface
dendrite
dendritic branch
dendritic spine
endoplasmic reticulum
excitatory synapse
integral component of plasma membrane
neuron projection
neuronal cell body
neuronal postsynaptic density
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic density
postsynaptic membrane
synapse
synaptic cleft
synaptic vesicle
terminal bouton
calcium channel activity
calcium ion binding
calmodulin binding
extracellular-glutamate-gated ion channel activity
glutamate binding
glycine binding
neurotransmitter binding
NMDA glutamate receptor activity
voltage-gated cation channel activity
activation of MAPKK activity
adult locomotory behavior
axon guidance
calcium ion homeostasis
calcium ion transmembrane transport
cation transport
cellular calcium ion homeostasis
cellular response to manganese ion
cerebral cortex development
conditioned taste aversion
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
ionotropic glutamate receptor signaling pathway
long-term memory
male mating behavior
MAPK cascade
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
olfactory learning
pons maturation
positive regulation of apoptotic process
positive regulation of excitatory postsynaptic potential
positive regulation of transcription from RNA polymerase II promoter
prepulse inhibition
propylene metabolic process
protein tetramerization
Ras protein signal transduction
regulation of axonogenesis
regulation of dendrite morphogenesis
regulation of long-term neuronal synaptic plasticity
regulation of membrane potential
regulation of respiratory gaseous exchange
regulation of synapse assembly
respiratory gaseous exchange
response to amphetamine
response to calcium ion
response to ethanol
response to fungicide
response to morphine
rhythmic process
sensory perception of pain
small GTPase mediated signal transduction
social behavior
suckling behavior
synaptic transmission
synaptic transmission, glutamatergic
vascular endothelial growth factor receptor signaling pathway
visual learning - Gene Ontology Biological Process:
- activation of MAPKK activity
adult locomotory behavior
axon guidance
calcium ion homeostasis
calcium ion transmembrane transport
cation transport
cellular calcium ion homeostasis
cellular response to manganese ion
cerebral cortex development
conditioned taste aversion
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
excitatory postsynaptic potential
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
ionotropic glutamate receptor signaling pathway
long-term memory
male mating behavior
MAPK cascade
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
olfactory learning
pons maturation
positive regulation of apoptotic process
positive regulation of excitatory postsynaptic potential
positive regulation of transcription from RNA polymerase II promoter
prepulse inhibition
propylene metabolic process
protein tetramerization
Ras protein signal transduction
regulation of axonogenesis
regulation of dendrite morphogenesis
regulation of long-term neuronal synaptic plasticity
regulation of membrane potential
regulation of respiratory gaseous exchange
regulation of synapse assembly
respiratory gaseous exchange
response to amphetamine
response to calcium ion
response to ethanol
response to fungicide
response to morphine
rhythmic process
sensory perception of pain
small GTPase mediated signal transduction
social behavior
suckling behavior
synaptic transmission
synaptic transmission, glutamatergic
vascular endothelial growth factor receptor signaling pathway
visual learning - Gene Ontology Molecular Function:
- calcium channel activity
calcium ion binding
calmodulin binding
extracellular-glutamate-gated ion channel activity
glutamate binding
glycine binding
neurotransmitter binding
NMDA glutamate receptor activity
voltage-gated cation channel activity - Gene Ontology Cellular Component:
- cell junction
cell surface
dendrite
dendritic branch
dendritic spine
endoplasmic reticulum
excitatory synapse
integral component of plasma membrane
neuronal cell body
neuronal postsynaptic density
neuron projection
NMDA selective glutamate receptor complex
plasma membrane
postsynaptic density
postsynaptic membrane
synapse
synaptic cleft
synaptic vesicle
terminal bouton - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Magnesium
Membrane
Mental retardation
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q62936