Names & Taxonomy

Uniprot ID:
Q03518
Entry Name:
TAP1_HUMAN
Status:
reviewed
Protein Names:
Antigen peptide transporter 1 (APT1) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein)
Gene Names:
TAP1 ABCB2 PSF1 RING4 Y3
Gene Names Primary:
TAP1
Organism:
Homo sapiens (Human)

Structure

Length:
808
Sequence:
MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVPMASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.

Function

Function:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Cross Reference Drug Bank:
DB01259
Gene Ontology Go:
endoplasmic reticulum membrane
host cell
integral component of endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrion
TAP complex
ADP binding
ATP binding
ATPase activity, coupled to transmembrane movement of substances
MHC class Ib protein binding
peptide antigen binding
peptide transporter activity
peptide-transporting ATPase activity
protein homodimerization activity
TAP1 binding
TAP2 binding
adaptive immune response
antigen processing and presentation of endogenous peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytosol to ER transport
defense response
intracellular transport of viral protein in host cell
peptide transport
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
protection from natural killer cell mediated cytotoxicity
transmembrane transport
Gene Ontology Biological Process:
adaptive immune response
antigen processing and presentation of endogenous peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytosol to ER transport
defense response
intracellular transport of viral protein in host cell
peptide transport
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
protection from natural killer cell mediated cytotoxicity
transmembrane transport
Gene Ontology Molecular Function:
ADP binding
ATPase activity, coupled to transmembrane movement of substances
ATP binding
MHC class Ib protein binding
peptide antigen binding
peptide transporter activity
peptide-transporting ATPase activity
protein homodimerization activity
TAP1 binding
TAP2 binding
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
host cell
integral component of endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrion
TAP complex
Keywords:
3D-structure
ATP-binding
Adaptive immunity
Complete proteome
Endoplasmic reticulum
Host-virus interaction
Immunity
Membrane
Nucleotide-binding
Peptide transport
Polymorphism
Protein transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
P0C739; P27797; Q77CE4; P07237; P30101; Q03519; O15533; Q13769

Publication

PubMed ID:
2259383 1453454 8568858 14574404 15489334 8248212 2259384 8168860 1946428 7760936 8670825 8955196 9310490 9175839 10074494 10227971 11157746 15488952 19201886 21269460 25944712 11532960 1570316 8640228 11250043 12878362