Names & Taxonomy
- Uniprot ID:
- Q03426
- Entry Name:
- KIME_HUMAN
- Status:
- reviewed
- Protein Names:
- Mevalonate kinase (MK) (EC 2.7.1.36)
- Gene Names:
- MVK
- Gene Names Primary:
- MVK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 396
- Sequence:
- MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May be a regulatory site in cholesterol biosynthetic pathway.
- Pathway:
- Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
- Catalytic Activity:
- ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
- Enzyme Regulation:
- ENZYME REGULATION: Farnesyl- and geranyl-pyrophosphates are competitive inhibitors.
- Active Site:
- ACT_SITE 204 204 Proton acceptor.
- Gene Ontology Go:
- cytosol
extracellular exosome
ATP binding
identical protein binding
mevalonate kinase activity
cholesterol biosynthetic process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process
negative regulation of inflammatory response
small molecule metabolic process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process
negative regulation of inflammatory response
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
identical protein binding
mevalonate kinase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
ATP-binding
Cataract
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Cytoplasm
Disease mutation
Kinase
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase - Interacts With:
- Itself; Q9NUX5