Names & Taxonomy

Uniprot ID:
Q03405
Entry Name:
UPAR_HUMAN
Status:
reviewed
Protein Names:
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)
Gene Names:
PLAUR MO3 UPAR
Gene Names Primary:
PLAUR
Organism:
Homo sapiens (Human)

Structure

Length:
335
Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Cross Reference Drug Bank:
DB00009 DB00029 DB00015 DB00031 DB00013
Gene Ontology Go:
anchored component of membrane
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
extrinsic component of membrane
focal adhesion
integral component of membrane
integral component of plasma membrane
invadopodium membrane
plasma membrane
enzyme binding
protein domain specific binding
receptor activity
receptor binding
urokinase plasminogen activator receptor activity
attachment of GPI anchor to protein
blood coagulation
C-terminal protein lipidation
cellular protein metabolic process
chemotaxis
fibrinolysis
movement of cell or subcellular component
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein phosphorylation
positive regulation of release of cytochrome c from mitochondria
post-translational protein modification
regulation of proteolysis
signal transduction
urokinase plasminogen activator signaling pathway
Gene Ontology Biological Process:
attachment of GPI anchor to protein
blood coagulation
cellular protein metabolic process
chemotaxis
C-terminal protein lipidation
fibrinolysis
movement of cell or subcellular component
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein phosphorylation
positive regulation of release of cytochrome c from mitochondria
post-translational protein modification
regulation of proteolysis
signal transduction
urokinase plasminogen activator signaling pathway
Gene Ontology Molecular Function:
enzyme binding
protein domain specific binding
receptor activity
receptor binding
urokinase plasminogen activator receptor activity
Gene Ontology Cellular Component:
anchored component of membrane
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
extrinsic component of membrane
focal adhesion
integral component of membrane
integral component of plasma membrane
invadopodium membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
1689240 1316922 8131971 8392005 8049431 14702039 15057824 15489334 11051819 7605992 2156852 9030717 7539799 8394346 10636902 12376466 14517339 14764453 16602701 18718938 15861141 16456079 22285761