Names & Taxonomy
- Uniprot ID:
- Q03405
- Entry Name:
- UPAR_HUMAN
- Status:
- reviewed
- Protein Names:
- Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)
- Gene Names:
- PLAUR MO3 UPAR
- Gene Names Primary:
- PLAUR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 335
- Sequence:
- MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
- Cross Reference Drug Bank:
- DB00009 DB00029 DB00015 DB00031 DB00013
- Gene Ontology Go:
- anchored component of membrane
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
extrinsic component of membrane
focal adhesion
integral component of membrane
integral component of plasma membrane
invadopodium membrane
plasma membrane
enzyme binding
protein domain specific binding
receptor activity
receptor binding
urokinase plasminogen activator receptor activity
attachment of GPI anchor to protein
blood coagulation
C-terminal protein lipidation
cellular protein metabolic process
chemotaxis
fibrinolysis
movement of cell or subcellular component
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein phosphorylation
positive regulation of release of cytochrome c from mitochondria
post-translational protein modification
regulation of proteolysis
signal transduction
urokinase plasminogen activator signaling pathway - Gene Ontology Biological Process:
- attachment of GPI anchor to protein
blood coagulation
cellular protein metabolic process
chemotaxis
C-terminal protein lipidation
fibrinolysis
movement of cell or subcellular component
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein phosphorylation
positive regulation of release of cytochrome c from mitochondria
post-translational protein modification
regulation of proteolysis
signal transduction
urokinase plasminogen activator signaling pathway - Gene Ontology Molecular Function:
- enzyme binding
protein domain specific binding
receptor activity
receptor binding
urokinase plasminogen activator receptor activity - Gene Ontology Cellular Component:
- anchored component of membrane
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
extrinsic component of membrane
focal adhesion
integral component of membrane
integral component of plasma membrane
invadopodium membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal