Names & Taxonomy
- Uniprot ID:
- Q03393
- Entry Name:
- PTPS_HUMAN
- Status:
- reviewed
- Protein Names:
- 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12)
- Gene Names:
- PTS
- Gene Names Primary:
- PTS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 145
- Sequence:
- MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
- Proteomes:
- UP000005640
Function
- Function:
- Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
- Pathway:
- Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
- Catalytic Activity:
- 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=8.1 uM for 7,8-dihydroneopterin triphosphate
- Active Site:
- ACT_SITE 43 43 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
mitochondrion
6-pyruvoyltetrahydropterin synthase activity
identical protein binding
metal ion binding
cellular amino acid metabolic process
central nervous system development
nitric oxide metabolic process
regulation of nitric-oxide synthase activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process - Gene Ontology Biological Process:
- cellular amino acid metabolic process
central nervous system development
nitric oxide metabolic process
regulation of nitric-oxide synthase activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process - Gene Ontology Molecular Function:
- 6-pyruvoyltetrahydropterin synthase activity
identical protein binding
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
mitochondrion - Keywords:
- 3D-structure
Complete proteome
Disease mutation
Lyase
Metal-binding
Phenylketonuria
Phosphoprotein
Reference proteome
Tetrahydrobiopterin biosynthesis
Zinc - Interacts With:
- Itself; P38432; Q8TBB1; O00560; Q9P2Z0