Names & Taxonomy
- Uniprot ID:
- Q03154
- Entry Name:
- ACY1_HUMAN
- Status:
- reviewed
- Protein Names:
- Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase)
- Gene Names:
- ACY1
- Gene Names Primary:
- ACY1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 408
- Sequence:
- MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
- Catalytic Activity:
- An N-acyl-aliphatic-L-amino acid + H(2)O = an aliphatic L-amino acid + a carboxylate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 82 82
- Cross Reference Drug Bank:
- DB06151 DB00128
- Gene Ontology Go:
- cytosol
extracellular exosome
aminoacylase activity
metal ion binding
metallopeptidase activity
cellular amino acid metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular amino acid metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aminoacylase activity
metal ion binding
metallopeptidase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Hydrolase
Metal-binding
Polymorphism
Reference proteome
Zinc - Interacts With:
- P54274