Names & Taxonomy

Uniprot ID:
Q03154
Entry Name:
ACY1_HUMAN
Status:
reviewed
Protein Names:
Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase)
Gene Names:
ACY1
Gene Names Primary:
ACY1
Organism:
Homo sapiens (Human)

Structure

Length:
408
Sequence:
MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Catalytic Activity:
An N-acyl-aliphatic-L-amino acid + H(2)O = an aliphatic L-amino acid + a carboxylate.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 82 82
Cross Reference Drug Bank:
DB06151 DB00128
Gene Ontology Go:
cytosol
extracellular exosome
aminoacylase activity
metal ion binding
metallopeptidase activity
cellular amino acid metabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular amino acid metabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
aminoacylase activity
metal ion binding
metallopeptidase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Hydrolase
Metal-binding
Polymorphism
Reference proteome
Zinc
Interacts With:
P54274

Publication

PubMed ID:
8357837 8394326 16641997 15489334 21269460 22905912 24275569 12933810 16274666 16465618 16959974 17562838 21414403