Names & Taxonomy
- Uniprot ID:
- Q02809
- Entry Name:
- PLOD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)
- Gene Names:
- PLOD1 LLH PLOD
- Gene Names Primary:
- PLOD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 727
- Sequence:
- MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGLGEDWNVEKGTSAGGGQKVRLLKKALEKHADKEDLVILFADSYDVLFASGPRELLKKFRQARSQVVFSAEELIYPDRRLETKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQLFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGHVRARNLAYDTLPVLIHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPFVSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQSVKLVGPEVRMANADARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTRHGRLWSNFWGALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHSKLDPDMAFCANIRQQDVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYTKALAGKLVETPCPDVYWFPIFTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTIDIHMNQIGFEREWHKFLLEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDASTFTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYIAVSFVDP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Function
- Function:
- Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
- Catalytic Activity:
- L-lysine- + 2-oxoglutarate + O(2) = (2S,5R)-5-hydroxy-L-lysine- + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875; ; COFACTOR: Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
- Active Site:
- ACT_SITE 718 718
- Cross Reference Drug Bank:
- DB00139 DB00126
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
rough endoplasmic reticulum membrane
ferrous iron binding
L-ascorbic acid binding
peptide binding
procollagen-lysine 5-dioxygenase activity
protein homodimerization activity
cellular protein modification process
cellular response to hormone stimulus
epidermis development
extracellular matrix organization
hydroxylysine biosynthetic process
oxidation-reduction process
peptidyl-lysine hydroxylation
response to hypoxia - Gene Ontology Biological Process:
- cellular protein modification process
cellular response to hormone stimulus
epidermis development
extracellular matrix organization
hydroxylysine biosynthetic process
oxidation-reduction process
peptidyl-lysine hydroxylation
response to hypoxia - Gene Ontology Molecular Function:
- ferrous iron binding
L-ascorbic acid binding
peptide binding
procollagen-lysine 5-dioxygenase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome
rough endoplasmic reticulum membrane - Keywords:
- Alternative splicing
Complete proteome
Dioxygenase
Direct protein sequencing
Disease mutation
Ehlers-Danlos syndrome
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Signal
Vitamin C